Optical coherence tomography (OCT) is a promising non-contact and high resolution 3-dimensional imaging technique that utilizes backscattering light to image tissue structures in vivo. Rigorous investigation into the properties of specific vascular beds, therefore, has the potential to further improve our understanding in disease pathogenesis, and lead to novel methods for the prevention and treatment of human disease. For instance, in neurology, dysregulated angiogenesis is implicated in stroke, Alzheimer’s disease and motor neuron disease in ophthalmology, evidence of vascular remodeling provides a critical indication of disease progression in oncology, the study of irregular tumor vessels can inform drug delivery strategies and during wound healing, specific vessel parameters have been shown to correlate with wound recovery time. The vasculature plays an important role in tissue development and remodeling under both normal and pathological conditions. We believe this framework would be useful for the diagnosis of vascular diseases, especially those resulting in regional early-stage morphological changes. From our tracing process, vessel tortuosity and branching angle could also be measured, establishing our approach as an automatic vasculature evaluation framework. Our algorithm returned results that followed Murray’s law, until reaching the capillary level, agreeing well with known physiological data. After validation in vitro, we applied these algorithms to the in vivo setting through analysis of mouse cortical vasculature. We also incorporated a modified A* path searching algorithm to trace vessel branches and calculate the diameter of each branch from the OCTA images. Compared to traditional methods, our method demonstrated superior consistency and accuracy, as well as high tolerance to rotation of the vasculature pattern, during validation using well-characterized microfluidic flow phantoms. In this paper, we present a method for automatic vessel diameter mapping down to the individual capillary level, through gradient-guided mimimum radial distance (MRD). Following improvements in OCTA image quality, it is now possible to extract vascular parameters from image data to potentially facilitate the diagnosis and treatment of human disease. Its comprehensive interface and shortcut associations make it a useful tool for technical designers.Optical coherence tomography angiography (OCTA) is capable of non-invasively imaging the vascular networks within circulatory tissue beds in vivo. The application supports handling large designs, loading large files, importing elements or painting complex layouts can easily be performed. LayoutEditor is a powerful program that allows you to create several types of technical designs and schematics. The application uses a multitude of file formats, including Calma GDSII, OASIS, OpenAccess, CIF, DXF, Gerber, LEF, DEF, Lasi, SVG, CSV, PNG, Alliance, ODB++, EDIF or Qucs. Moreover, it allows you to manually modify the netlist, using the designated text editor. It also displays connections, device names, indicated routes, as well as extraction methods, for building connections or setting node modes. You may easily export netlists or import them from local files. The column on the left lists all the layers with their afferent names, as well as the current mouse shortcuts, while the panel on the right allows you to select netlist elements. LayoutEditor features a divided interface, with the main drawing area framed by useful function panels. User-friendly interface for a quick design process Additionally, you can assign a multitude of functions to keyboard shortcuts. The application offers several types of tools for drawing and quickly switching between layers, as well as pre-defined shapes or the ability to make custom selections. It is also suitable for the design of printed circuit boards (PCB), GDS thick film technology or thin film technology. It can come in handy when creating Multi-Chip-Modules (MCM), Chip-on-Board (COB), Low temperature co-fired ceramics (LTCC) or Monolithic Microwave Integrated Circuits (MMIC). LayoutEditor is a simple to use application which facilitates the design of circuits, chip boards or film technology. It is also suitable for designing circuits or film technologies. Moreover, the application offers a multitude of editing tools, designed to make the creation process faster and easier. LayoutEditor is a comprehensive program that allows you to quickly create, modify or export layout designs for MEMS/IC products.
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